Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1

F Van Hauwermeiren, RE Vandenbroucke… - Cytokine & growth factor …, 2011 - Elsevier
The TNF signaling pathway is a valuable target in the therapy of autoimmune diseases, and
anti-TNF drugs are successfully used to treat diseases such as rheumatoid arthritis, Crohn's
disease and psoriasis. By their ability to interfere with inflammatory processes at multiple
levels, these TNF blockers have become invaluable tools to inhibit the inflammation induced
damage and allow recovery of the affected tissues. Unfortunately this therapy has some
drawbacks, including increased risk of infection and malignancy, and remarkably, the onset …