[HTML][HTML] The proteomic profile of circulating pentraxin 3 (PTX3) complex in sepsis demonstrates the interaction with azurocidin 1 and other components of neutrophil …
K Daigo, N Yamaguchi, T Kawamura… - Molecular & Cellular …, 2012 - ASBMB
Pentraxin 3 (PTX3), a long pentraxin subfamily member in the pentraxin family, plays an
important role in innate immunity as a soluble pattern recognition receptor. Plasma PTX3 is
elevated in sepsis (∼ 200 ng/ml) and correlates with mortality. The roles of PTX3 in sepsis,
however, are not well understood. To investigate the ligands of PTX3 in sepsis, we
performed a targeted proteomic study of circulating PTX3 complexes using magnetic bead-
based immunopurification and shotgun proteomics for label-free relative quantitation via …
important role in innate immunity as a soluble pattern recognition receptor. Plasma PTX3 is
elevated in sepsis (∼ 200 ng/ml) and correlates with mortality. The roles of PTX3 in sepsis,
however, are not well understood. To investigate the ligands of PTX3 in sepsis, we
performed a targeted proteomic study of circulating PTX3 complexes using magnetic bead-
based immunopurification and shotgun proteomics for label-free relative quantitation via …