[HTML][HTML] FOXO1 represses peroxisome proliferator-activated receptor-γ1 and-γ2 gene promoters in primary adipocytes: a novel paradigm to increase insulin sensitivity
M Armoni, C Harel, S Karni, H Chen… - Journal of Biological …, 2006 - ASBMB
FOXO1 and peroxisome proliferator-activated receptor-γ (PPARγ) are crucial transcription
factors that regulate glucose metabolism and insulin responsiveness in insulin target
tissues. We have shown that, in primary rat adipocytes, both factors regulate transcription of
the insulin-responsive GLUT4 gene and that PPARγ2 detachment from the GLUT4 promoter
upon thiazolidinedione binding up-regulates GLUT4 gene expression, thus increasing
insulin sensitivity (Armoni, M., Kritz, N., Harel, C., Bar-Yoseph, F., Chen, H., Quon, MJ, and …
factors that regulate glucose metabolism and insulin responsiveness in insulin target
tissues. We have shown that, in primary rat adipocytes, both factors regulate transcription of
the insulin-responsive GLUT4 gene and that PPARγ2 detachment from the GLUT4 promoter
upon thiazolidinedione binding up-regulates GLUT4 gene expression, thus increasing
insulin sensitivity (Armoni, M., Kritz, N., Harel, C., Bar-Yoseph, F., Chen, H., Quon, MJ, and …