Tactile allodynia in the absence of C-fiber activation: altered firing properties of DRG neurons following spinal nerve injury

CN Liu, PD Wall, E Ben-Dor, M Michaelis, R Amir… - Pain, 2000 - Elsevier
We examined the relation between ectopic afferent firing and tactile allodynia in the Chung
model of neuropathic pain. Transection of the L5 spinal nerve in rats triggered a sharp, four-
to six-fold increase in the spontaneous ectopic discharge recorded in vivo in sensory axons
in the ipsilateral L5 dorsal root (DR). The increase, which was not yet apparent 16 h
postoperatively, was complete by 24 h. This indicates rapid modification of the electrical
properties of the neurons. Only A-neurons, primarily rapidly conducting A-neurons …