[HTML][HTML] Akt phosphorylates Wnt coactivator and chromatin effector Pygo2 at serine 48 to antagonize its ubiquitin/proteasome-mediated degradation

Q Li, Y Li, B Gu, L Fang, P Zhou, S Bao, L Huang… - Journal of Biological …, 2015 - ASBMB
Pygopus 2 (Pygo2/PYGO2) is an evolutionarily conserved coactivator and chromatin effector
in the Wnt/β-catenin signaling pathway that regulates cell growth and differentiation in
various normal and malignant tissues. Although PYGO2 is highly overexpressed in a
number of human cancers, the molecular mechanism underlying its deregulation is largely
unknown. Here we report that Pygo2 protein is degraded through the ubiquitin/proteasome
pathway and is posttranslationally stabilized through phosphorylation by activated …