[HTML][HTML] The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate
Y Li, P Trojer, CF Xu, P Cheung, A Kuo… - Journal of Biological …, 2009 - ASBMB
The NSD (nuclear receptor SET domain-containing) family of histone lysine
methyltransferases is a critical participant in chromatin integrity as evidenced by the number
of human diseases associated with the aberrant expression of its family members. Yet, the
specific targets of these enzymes are not clear, with marked discrepancies being reported in
the literature. We demonstrate that NSD2 can exhibit disparate target preferences based on
the nature of the substrate provided. The NSD2 complex purified from human cells and …
methyltransferases is a critical participant in chromatin integrity as evidenced by the number
of human diseases associated with the aberrant expression of its family members. Yet, the
specific targets of these enzymes are not clear, with marked discrepancies being reported in
the literature. We demonstrate that NSD2 can exhibit disparate target preferences based on
the nature of the substrate provided. The NSD2 complex purified from human cells and …