[HTML][HTML] Negative feed-forward control of tumor necrosis factor (TNF) by tristetraprolin (ZFP36) is limited by the mitogen-activated protein kinase phosphatase, dual …
S Shah, MM Mostafa, A McWhae, SL Traves… - Journal of Biological …, 2016 - ASBMB
TNF is central to inflammation and may play a role in the pathogenesis of asthma. The 3′-
untranslated region of the TNF transcript contains AU-rich elements (AREs) that are targeted
by the RNA-binding protein, tristetraprolin (also known as zinc finger protein 36 (ZFP36)),
which is itself up-regulated by inflammatory stimuli, to promote mRNA degradation. Using
primary human bronchial epithelial and pulmonary epithelial A549 cells, we confirm that
interleukin-1β (IL1B) induces expression of dual-specificity phosphatase 1 (DUSP1), ZFP36 …
untranslated region of the TNF transcript contains AU-rich elements (AREs) that are targeted
by the RNA-binding protein, tristetraprolin (also known as zinc finger protein 36 (ZFP36)),
which is itself up-regulated by inflammatory stimuli, to promote mRNA degradation. Using
primary human bronchial epithelial and pulmonary epithelial A549 cells, we confirm that
interleukin-1β (IL1B) induces expression of dual-specificity phosphatase 1 (DUSP1), ZFP36 …