[HTML][HTML] Medroxyprogesterone acetate differentially regulates interleukin (IL)-12 and IL-10 in a human ectocervical epithelial cell line in a glucocorticoid receptor (GR) …
Medroxyprogesterone acetate (MPA), designed to mimic the actions of the endogenous
hormone progesterone (P 4), is extensively used by women as a contraceptive and in
hormone replacement therapy. However, little is known about the steroid receptor-mediated
molecular mechanisms of action of MPA in the female genital tract. In this study, we
investigated the regulation of the pro-inflammatory cytokine, interleukin (IL)-12, and the anti-
inflammatory cytokine IL-10, by MPA versus P 4, in an in vitro cell culture model of the …
hormone progesterone (P 4), is extensively used by women as a contraceptive and in
hormone replacement therapy. However, little is known about the steroid receptor-mediated
molecular mechanisms of action of MPA in the female genital tract. In this study, we
investigated the regulation of the pro-inflammatory cytokine, interleukin (IL)-12, and the anti-
inflammatory cytokine IL-10, by MPA versus P 4, in an in vitro cell culture model of the …