Glucocorticoids severely impair differentiation and antigen presenting function of dendritic cells despite upregulation of Toll-like receptors
D Rozkova, R Horvath, J Bartunkova, R Spisek - Clinical immunology, 2006 - Elsevier
Glucocorticoids (GCs) are widely used as anti-inflammatory and immunosuppressive
agents. Effects of GC have mainly been attributed to the suppression of T cells. Recently,
several studies have indicated the role of dendritic cells (DC) in GC-mediated
immunosuppression. We investigated the effect of GC on characteristics of DC. Given the
crucial role of Toll-like receptor (TLR) triggering for the initiation of DC maturation program,
we analyzed the expression of TLR2, 3, 4 by GC-treated DC. To extend our in vitro findings …
agents. Effects of GC have mainly been attributed to the suppression of T cells. Recently,
several studies have indicated the role of dendritic cells (DC) in GC-mediated
immunosuppression. We investigated the effect of GC on characteristics of DC. Given the
crucial role of Toll-like receptor (TLR) triggering for the initiation of DC maturation program,
we analyzed the expression of TLR2, 3, 4 by GC-treated DC. To extend our in vitro findings …