[HTML][HTML] Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization [S]
LC Chao, K Wroblewski, OR Ilkayeva, RD Stevens… - Journal of lipid …, 2012 - ASBMB
Mitochondrial dysfunction has been implicated in the pathogenesis of type 2 diabetes.
Identifying novel regulators of mitochondrial bioenergetics will broaden our understanding of
regulatory checkpoints that coordinate complex metabolic pathways. We previously showed
that Nur77, an orphan nuclear receptor of the NR4A family, regulates the expression of
genes linked to glucose utilization. Here we demonstrate that expression of Nur77 in
skeletal muscle also enhances mitochondrial function. We generated MCK-Nur77 …
Identifying novel regulators of mitochondrial bioenergetics will broaden our understanding of
regulatory checkpoints that coordinate complex metabolic pathways. We previously showed
that Nur77, an orphan nuclear receptor of the NR4A family, regulates the expression of
genes linked to glucose utilization. Here we demonstrate that expression of Nur77 in
skeletal muscle also enhances mitochondrial function. We generated MCK-Nur77 …