The expression of several genes involved in intra-and extracellular lipid metabolism, notably
those involved in peroxisomal and mitochondrial β-oxidation, is mediated by ligand-
activated receptors, collectively referred to as peroxisome proliferator-activated receptors
(PPARs). To gain more insight into the control of expression of carnitine palmitoyltransferase
(CPT) genes, which are regulated by fatty acids, we have examined the transcriptional
regulation of the human MCPT I gene. We have cloned by polymerase chain reaction the …