[HTML][HTML] Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1
K Yamagata, H Daitoku, Y Shimamoto… - Journal of Biological …, 2004 - ASBMB
Bile acid homeostasis is tightly controlled by the feedback mechanism in which an atypical
orphan nuclear receptor (NR) small heterodimer partner (SHP) inactivates several NRs such
as liver receptor homologue-1 and hepatocyte nuclear factor 4. Although NRs have been
implicated in the transcriptional regulation of gluconeogenic genes, the effect of bile acids
on gluconeogenic gene expression remained unknown. Here, we report that bile acids
inhibit the expression of gluconeogenic genes, including glucose-6-phosphatase (G6Pase) …
orphan nuclear receptor (NR) small heterodimer partner (SHP) inactivates several NRs such
as liver receptor homologue-1 and hepatocyte nuclear factor 4. Although NRs have been
implicated in the transcriptional regulation of gluconeogenic genes, the effect of bile acids
on gluconeogenic gene expression remained unknown. Here, we report that bile acids
inhibit the expression of gluconeogenic genes, including glucose-6-phosphatase (G6Pase) …