[HTML][HTML] Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction

T van Zutphen, J Ciapaite, VW Bloks, C Ackereley… - Journal of …, 2016 - Elsevier
Background & Aims Severe malnutrition in young children is associated with signs of hepatic
dysfunction such as steatosis and hypoalbuminemia, but its etiology is unknown.
Peroxisomes and mitochondria play key roles in various hepatic metabolic functions
including lipid metabolism and energy production. To investigate the involvement of these
organelles in the mechanisms underlying malnutrition-induced hepatic dysfunction we
developed a rat model of malnutrition. Methods Weanling rats were placed on a low protein …