[HTML][HTML] A binding domain on mesothelin for CA125/MUC16
O Kaneko, L Gong, J Zhang, JK Hansen… - Journal of biological …, 2009 - ASBMB
Ovarian cancer and malignant mesothelioma frequently express both mesothelin and
CA125 (also known as MUC16) at high levels on the cell surface. The interaction between
mesothelin and CA125 may facilitate the implantation and peritoneal spread of tumors by
cell adhesion, whereas the detailed nature of this interaction is still unknown. Here, we used
truncated mutagenesis and alanine replacement techniques to identify a binding site on
mesothelin for CA125. We examined the molecular interaction by Western blot overlay …
CA125 (also known as MUC16) at high levels on the cell surface. The interaction between
mesothelin and CA125 may facilitate the implantation and peritoneal spread of tumors by
cell adhesion, whereas the detailed nature of this interaction is still unknown. Here, we used
truncated mutagenesis and alanine replacement techniques to identify a binding site on
mesothelin for CA125. We examined the molecular interaction by Western blot overlay …