[HTML][HTML] Activation of AXIN2 expression by β-catenin-T cell factor: a feedback repressor pathway regulating Wnt signaling

JY Leung, FT Kolligs, R Wu, Y Zhai, R Kuick… - Journal of Biological …, 2002 - ASBMB
The Wnt pathway regulates cell fate, proliferation, and apoptosis, and defects in the pathway
play a key role in many cancers. Although Wnts act to stabilize β-catenin levels in the cytosol
and nucleus, a multiprotein complex containing adenomatous polyposis coli, glycogen
synthase kinase 3β, and Axin1 or its homolog Axin2/Axil/conductin promotes β-catenin
phosphorylation and subsequent proteasomal degradation. We found that the rat Axil gene
was strongly induced upon neoplastic transformation of RK3E cells by mutant β-catenin or γ …