Human cytomegalovirus immunity and immune evasion
SE Jackson, GM Mason, MR Wills - Virus research, 2011 - Elsevier
Human cytomegalovirus (HCMV) infection induces both innate immune responses including
Natural Killer cells as well as adaptive humoral and cell mediated (CD4+ helper, CD8+
cytotoxic and γδ T cell) responses which lead to the resolution of acute primary infection.
Despite such a robust primary immune response, HCMV is still able to establish latency.
Long term memory T cell responses are maintained at high frequency and are thought to
prevent clinical disease following periodic reactivation of the virus. As such, a balance is …
Natural Killer cells as well as adaptive humoral and cell mediated (CD4+ helper, CD8+
cytotoxic and γδ T cell) responses which lead to the resolution of acute primary infection.
Despite such a robust primary immune response, HCMV is still able to establish latency.
Long term memory T cell responses are maintained at high frequency and are thought to
prevent clinical disease following periodic reactivation of the virus. As such, a balance is …