The c-erb-A protein is a high-affinity receptor for thyroid hormone

J Sap, A Muñoz, K Damm, Y Goldberg, J Ghysdael… - Nature, 1986 - nature.com
J Sap, A Muñoz, K Damm, Y Goldberg, J Ghysdael, A Leutz, H Beug, B Vennström
Nature, 1986nature.com
Hormone binding and localization of the c-erb-A protein suggest that it is a receptor for
thyroid hormone, a nuclear protein that binds to DNA and activates transcription. In contrast,
the product of the viral oncogene v-erb-A is defective in binding the hormone but is still
located in the nucleus.
Abstract
Hormone binding and localization of the c-erb-A protein suggest that it is a receptor for thyroid hormone, a nuclear protein that binds to DNA and activates transcription. In contrast, the product of the viral oncogene v-erb-A is defective in binding the hormone but is still located in the nucleus.
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