PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

S Francque, A Verrijken, S Caron, J Prawitt… - Journal of …, 2015 - Elsevier
Background & Aims Peroxisome proliferator-activated receptors (PPARs) have been
implicated in non-alcoholic steatohepatitis (NASH) pathogenesis, mainly based on animal
data. Gene expression data in NASH patients are scarce. We studied liver PPARα, β/δ, and
γ expression in a large cohort of obese patients assessed for presence of NAFLD at
baseline and 1 year follow-up. Methods Patients presented to the obesity clinic underwent a
hepatic work-up. If NAFLD was suspected, liver biopsy was performed. Gene expression …