[HTML][HTML] Disturbances in the normal regulation of SREBP-sensitive genes in PPARα-deficient mice

DD Patel, BL Knight, D Wiggins, SM Humphreys… - Journal of lipid …, 2001 - ASBMB
Peroxisome proliferator-activated receptor α (PPARα)-null mice were used to investigate the
nature of the relationship between the normal circadian rhythm of hepatic PPARα
expression and the expression of the lipogenic and cholesterogenic sterol regulatory
element-binding protein (SREBP)-regulated genes, acetyl-CoA carboxylase, fatty acid
synthase (FAS), and 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoAR). The
expression of FAS and HMG-CoAR varied rhythmically over the diurnal cycle in the normal …