[HTML][HTML] Peroxisome proliferator-activated receptor α positively regulates complement C3 expression but inhibits tumor necrosis factor α-mediated activation of C3 …
DA Mogilenko, IV Kudriavtsev, VS Shavva… - Journal of Biological …, 2013 - ASBMB
Complement C3 is a pivotal component of three cascades of complement activation. The
liver is the main source of C3 in circulation and expression and secretion of C3 by
hepatocytes is increased during acute inflammation. However, the mechanism of the
regulation of the C3 gene in hepatocytes is not well elucidated. We showed that the C3 gene
is the direct target for peroxisome proliferator-activated receptor α (PPARα) in human
hepatoma HepG2 cells and mouse liver. Using PPARα siRNA and synthetic PPARα agonist …
liver is the main source of C3 in circulation and expression and secretion of C3 by
hepatocytes is increased during acute inflammation. However, the mechanism of the
regulation of the C3 gene in hepatocytes is not well elucidated. We showed that the C3 gene
is the direct target for peroxisome proliferator-activated receptor α (PPARα) in human
hepatoma HepG2 cells and mouse liver. Using PPARα siRNA and synthetic PPARα agonist …