Predictors of clinical outcome in patients with heparin-induced thrombocytopenia treated with direct thrombin inhibition
JG Kelton, MJ Hursting, N Heddle… - Blood coagulation & …, 2008 - journals.lww.com
We aimed to identify predictors of poor outcome in patients with heparin-induced
thrombocytopenia, a serious immune-mediated reaction to heparin. All patients were treated
with direct thrombin inhibition therapy, as part of two prospective studies. We performed a
risk factor analysis of adverse outcomes (defined as death, amputation, new thrombosis, or
their composite within a 37-day study period) in 809 patients from two reported prospective
studies of the direct thrombin inhibitor argatroban in clinically diagnosed heparin-induced …
thrombocytopenia, a serious immune-mediated reaction to heparin. All patients were treated
with direct thrombin inhibition therapy, as part of two prospective studies. We performed a
risk factor analysis of adverse outcomes (defined as death, amputation, new thrombosis, or
their composite within a 37-day study period) in 809 patients from two reported prospective
studies of the direct thrombin inhibitor argatroban in clinically diagnosed heparin-induced …