[HTML][HTML] Conjugation of LG domains of agrins and perlecan to polymerizing laminin-2 promotes acetylcholine receptor clustering

SP Smirnov, P Barzaghi, KK McKee, MA Ruegg… - Journal of Biological …, 2005 - ASBMB
Neuromuscular junction (NMJ) assembly is characterized by the clustering and neuronal
alignment of acetylcholine receptors (AChRs). In this study we have addressed post-
synaptic contributions to assembly that may arise from the NMJ basement membrane with
cultured myotubes. We show that the cell surface-binding LG domains of non-neural
(muscle) agrin and perlecan promote AChR clustering in the presence of laminin-2. This
type of AChR clustering occurs with a several hour lag, requires muscle-specific kinase …