[HTML][HTML] Self-assembly of laminin isoforms

YS Cheng, MF Champliaud, RE Burgeson… - Journal of Biological …, 1997 - ASBMB
The α, β, and γ subunits of basement membrane laminins can combine into different
heterotrimeric molecules with either three full short arms (eg laminins-1–4), or molecules
containing one (laminins-6–9) or more (laminin-5) short arm truncations. Laminin-1
(α1β1γ1), self-assembles through a calcium-dependent thermal gelation requiring binding
interactions between N-terminal short arm domains, forming a meshwork polymer thought to
contribute to basement membrane architecture (Yurchenco, PD, and Cheng, YS (1993) J …