[HTML][HTML] Gonadotrope-specific deletion of Dicer results in severely suppressed gonadotropins and fertility defects

H Wang, I Graham, R Hastings, S Gunewardena… - Journal of Biological …, 2015 - ASBMB
Pituitary gonadotropins follicle-stimulating hormone and luteinizing hormone are
heterodimeric glycoproteins expressed in gonadotropes. They act on gonads and promote
their development and functions including steroidogenesis and gametogenesis. Although
transcriptional regulation of gonadotropin subunits has been well studied, the post-
transcriptional regulation of gonadotropin subunits is not well understood. To test if
microRNAs regulate the hormone-specific gonadotropin β subunits in vivo, we deleted Dicer …