[HTML][HTML] Role of the PD-1 pathway in the immune response
LV Riella, AM Paterson, AH Sharpe… - American Journal of …, 2012 - Elsevier
Understanding immunoregulatory mechanisms is essential for the development of novel
interventions to improve long-term allograft survival. Programmed death 1 (PD-1) and its
ligands, PD-L1 and PD-L2, have emerged as critical inhibitory signaling pathways that
regulate T cell response and maintain peripheral tolerance. PD-1 signaling inhibits
alloreactive T cell activation, and can promote induced regulatory T cell development.
Furthermore, the upregulation of PD-L1 on nonhematopoietic cells of the allograft may …
interventions to improve long-term allograft survival. Programmed death 1 (PD-1) and its
ligands, PD-L1 and PD-L2, have emerged as critical inhibitory signaling pathways that
regulate T cell response and maintain peripheral tolerance. PD-1 signaling inhibits
alloreactive T cell activation, and can promote induced regulatory T cell development.
Furthermore, the upregulation of PD-L1 on nonhematopoietic cells of the allograft may …