Ran GTPase protein promotes human pancreatic cancer proliferation by deregulating the expression of Survivin and cell cycle proteins

L Deng, Y Lu, X Zhao, Y Sun, Y Shi, H Fan, C Liu… - Biochemical and …, 2013 - Elsevier
L Deng, Y Lu, X Zhao, Y Sun, Y Shi, H Fan, C Liu, J Zhou, Y Nie, K Wu, D Fan, X Guo
Biochemical and biophysical research communications, 2013Elsevier
Ran, a member of the Ras GTPase family, has important roles in nucleocytoplasmic
transport. Herein, we detected Ran expression in pancreatic cancer and explored its
potential role on tumour progression. Overexpressed Ran in pancreatic cancer tissues was
found highly correlated with the histological grade. Downregulation of Ran led to significant
suppression of cell proliferation, cell cycle arrest at the G1/S phase and induction of
apoptosis. In vivo studies also validated that result. Further studies revealed that those …
Abstract
Ran, a member of the Ras GTPase family, has important roles in nucleocytoplasmic transport. Herein, we detected Ran expression in pancreatic cancer and explored its potential role on tumour progression. Overexpressed Ran in pancreatic cancer tissues was found highly correlated with the histological grade. Downregulation of Ran led to significant suppression of cell proliferation, cell cycle arrest at the G1/S phase and induction of apoptosis. In vivo studies also validated that result. Further studies revealed that those effects were at least partly mediated by the downregulation of Cyclin A, Cyclin D1, Cyclin E, CDK2, CDK4, phospho-Rb and Survivin proteins and up regulation of cleaved Caspase-3.
Elsevier