[HTML][HTML] Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues
AD Borowsky, P Bandhuvula, A Kumar… - Journal of lipid …, 2012 - ASBMB
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid involved in immunity,
inflammation, angiogenesis, and cancer. S1P lyase (SPL) is the essential enzyme
responsible for S1P degradation. SPL augments apoptosis and is down-regulated in cancer.
SPL generates a S1P chemical gradient that promotes lymphocyte trafficking and as such is
being targeted to treat autoimmune diseases. Despite growing interest in SPL as a disease
marker, antioncogene, and pharmacological target, no comprehensive characterization of …
inflammation, angiogenesis, and cancer. S1P lyase (SPL) is the essential enzyme
responsible for S1P degradation. SPL augments apoptosis and is down-regulated in cancer.
SPL generates a S1P chemical gradient that promotes lymphocyte trafficking and as such is
being targeted to treat autoimmune diseases. Despite growing interest in SPL as a disease
marker, antioncogene, and pharmacological target, no comprehensive characterization of …