Monocyte and macrophage heterogeneity in the heart

M Nahrendorf, FK Swirski - Circulation research, 2013 - Am Heart Assoc
Circulation research, 2013Am Heart Assoc
Monocytes and macrophages are innate immune cells that reside and accumulate in the
healthy and injured heart. The cells and their subsets pursue distinct functions in steady-
state and disease, and their tenure may range between hours and months. Some subsets
are highly inflammatory, whereas others support tissue repair. This review discusses current
concepts of lineage relationships and crosstalk of systems, highlights open questions, and
describes tools for studying monocyte and macrophage subsets in the murine and human …
Monocytes and macrophages are innate immune cells that reside and accumulate in the healthy and injured heart. The cells and their subsets pursue distinct functions in steady-state and disease, and their tenure may range between hours and months. Some subsets are highly inflammatory, whereas others support tissue repair. This review discusses current concepts of lineage relationships and crosstalk of systems, highlights open questions, and describes tools for studying monocyte and macrophage subsets in the murine and human heart.
Am Heart Assoc