Effect of IFN-ß therapy on the frequency and function of CD4+ CD25+ regulatory T cells and Foxp3 gene expression in relapsing–remitting multiple sclerosis (RRMS) …

A Namdar, B Nikbin, M Ghabaee, A Bayati… - Journal of …, 2010 - Elsevier
Interferon-ß (IFN-ß) is an immunomodulatory drug of choice to control relapsing–remitting
multiple sclerosis (RR-MS), although its function is still unclear. A reduced suppressive
function of CD4+ CD25+ regulatory T cells (Treg) has been shown in RR-MS patients. In this
study, to understand the effect of IFN-ß on CD4+ CD25+ regulatory T cells, we analyzed the
frequency and function of these cells and Foxp3 gene expression before and after treatment.
We evaluated the frequency and function of CD4+ CD25+ Foxp3+ regulatory T cells by flow …