Epicardial control of myocardial proliferation and morphogenesis
HM Sucov, Y Gu, S Thomas, P Li, M Pashmforoush - Pediatric cardiology, 2009 - Springer
HM Sucov, Y Gu, S Thomas, P Li, M Pashmforoush
Pediatric cardiology, 2009•SpringerThe epicardium is a critical tissue that directs several aspects of heart development,
particularly via the secretion of soluble factors. This review summarizes recent approaches
that implicate the epicardium as the source of mitogenic factors promoting cardiomyocyte
proliferation, as the source of instructive signals that direct compact zone organization
(morphogenesis), and as the tissue that directs formation of the coronary vasculature.
particularly via the secretion of soluble factors. This review summarizes recent approaches
that implicate the epicardium as the source of mitogenic factors promoting cardiomyocyte
proliferation, as the source of instructive signals that direct compact zone organization
(morphogenesis), and as the tissue that directs formation of the coronary vasculature.
Abstract
The epicardium is a critical tissue that directs several aspects of heart development, particularly via the secretion of soluble factors. This review summarizes recent approaches that implicate the epicardium as the source of mitogenic factors promoting cardiomyocyte proliferation, as the source of instructive signals that direct compact zone organization (morphogenesis), and as the tissue that directs formation of the coronary vasculature.
Springer