[HTML][HTML] The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology

AOH Hall, DP Beiting, C Tato, B John, G Oldenhove… - Immunity, 2012 - Elsevier
AOH Hall, DP Beiting, C Tato, B John, G Oldenhove, CG Lombana, GH Pritchard, JS Silver
Immunity, 2012Elsevier
Interferon-γ (IFN-γ) promotes a population of T-bet+ CXCR3+ regulatory T (Treg) cells that
limit T helper 1 (Th1) cell-mediated pathology. Our studies demonstrate that interleukin-27
(IL-27) also promoted expression of T-bet and CXCR3 in Treg cells. During infection with
Toxoplasma gondii, a similar population emerged that limited T cell responses and was
dependent on IFN-γ in the periphery but on IL-27 at mucosal sites. Transfer of Treg cells
ameliorated the infection-induced pathology observed in Il27−/− mice, and this was …
Interferon-γ (IFN-γ) promotes a population of T-bet+ CXCR3+ regulatory T (Treg) cells that limit T helper 1 (Th1) cell-mediated pathology. Our studies demonstrate that interleukin-27 (IL-27) also promoted expression of T-bet and CXCR3 in Treg cells. During infection with Toxoplasma gondii, a similar population emerged that limited T cell responses and was dependent on IFN-γ in the periphery but on IL-27 at mucosal sites. Transfer of Treg cells ameliorated the infection-induced pathology observed in Il27−/− mice, and this was dependent on their ability to produce IL-10. Microarray analysis revealed that Treg cells exposed to either IFN-γ or IL-27 have distinct transcriptional profiles. Thus, IFN-γ and IL-27 have different roles in Treg cell biology and IL-27 is a key cytokine that promotes the development of Treg cells specialized to control Th1 cell-mediated immunity at local sites of inflammation.
Elsevier