Inflammation in myocardial diseases

DJ Marchant, JH Boyd, DC Lin, DJ Granville… - Circulation …, 2012 - Am Heart Assoc
DJ Marchant, JH Boyd, DC Lin, DJ Granville, FS Garmaroudi, BM McManus
Circulation research, 2012Am Heart Assoc
Inflammatory processes underlie a broad spectrum of conditions that injure the heart muscle
and cause both structural and functional deficits. In this article, we address current
knowledge regarding 4 common forms of myocardial inflammation: myocardial ischemia and
reperfusion, sepsis, viral myocarditis, and immune rejection. Each of these pathological
states has its own unique features in pathogenesis and disease evolution, but all reflect
inflammatory mechanisms that are partially shared. From the point of injury to the …
Inflammatory processes underlie a broad spectrum of conditions that injure the heart muscle and cause both structural and functional deficits. In this article, we address current knowledge regarding 4 common forms of myocardial inflammation: myocardial ischemia and reperfusion, sepsis, viral myocarditis, and immune rejection. Each of these pathological states has its own unique features in pathogenesis and disease evolution, but all reflect inflammatory mechanisms that are partially shared. From the point of injury to the mobilization of innate and adaptive immune responses and inflammatory amplification, the cellular and soluble mediators and mechanisms examined in this review will be discussed with a view that both beneficial and adverse consequences arise in these human conditions.
Am Heart Assoc