[HTML][HTML] Hippo signaling goes long range
VA Codelia, KD Irvine - Cell, 2012 - cell.com
VA Codelia, KD Irvine
Cell, 2012•cell.comThe Hippo-YAP pathway regulates organ size by modulating cell proliferation and
apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the
transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin
cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular
regulators of YAP/TAZ activity.
apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the
transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin
cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular
regulators of YAP/TAZ activity.
The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular regulators of YAP/TAZ activity.
cell.com