[HTML][HTML] HIV-1 infection induces interleukin-1β production via TLR8 protein-dependent and NLRP3 inflammasome mechanisms in human monocytes
H Guo, J Gao, DJ Taxman, JPY Ting, L Su - Journal of Biological Chemistry, 2014 - ASBMB
The induction of inflammatory cytokines such as IL-1β is associated with the progression of
human immunodeficiency virus, type 1 (HIV-1) disease or AIDS. Unlike most inflammatory
cytokines that are regulated by NF-κB at the transcriptional level, production of mature IL-1β
also depends on inflammasome activation. The mechanism by which HIV-1 induces pro-IL-
1β expression and activates inflammasomes to cleave pro-IL-1β into its bioactive form is not
clearly defined. We report here that HIV-1 infection in human monocytes efficiently induced …
human immunodeficiency virus, type 1 (HIV-1) disease or AIDS. Unlike most inflammatory
cytokines that are regulated by NF-κB at the transcriptional level, production of mature IL-1β
also depends on inflammasome activation. The mechanism by which HIV-1 induces pro-IL-
1β expression and activates inflammasomes to cleave pro-IL-1β into its bioactive form is not
clearly defined. We report here that HIV-1 infection in human monocytes efficiently induced …