Chemokines are a key component of cancer-related inflammation. Chemokines and
chemokine receptors are downstream of genetic events that cause neoplastic transformation
and are components of chronic inflammatory conditions, which predispose to cancer.
Components of the chemokine system affect in a cell autonomous or non-autonomous way
multiple pathways of tumor progression, including: leukocyte recruitment and function;
cellular senescence; tumor cell proliferation and survival; invasion and metastasis. Available …