Prognostic significance and mechanism of Treg infiltration in human brain tumors

JFM Jacobs, AJ Idema, KF Bol, JA Grotenhuis… - Journal of …, 2010 - Elsevier
Regulatory T cells (Tregs) accumulate in tumors and can contribute to the dismal immune
responses observed in these tumors. We reported that the percentage of tumor infiltrating
Tregs is strongly correlated with the WHO grade of the brain tumor. We now report on the
clinical follow-up of this patient cohort (n= 83). Subgroup analyses in patients with
glioblastomas (n= 29) showed a moderate, not significant, inverted association between
Tregs and survival. We further show that Tregs in glioblastomas, in contrast to other tumor …