Spatiotemporal pattern of striatal ERK1/2 phosphorylation in a rat model of L-DOPA–induced dyskinesia and the role of dopamine D1 receptors

JE Westin, L Vercammen, EM Strome, C Konradi… - Biological …, 2007 - Elsevier
BACKGROUND: We examined the activation pattern of extracellular signal-regulated kinase
1 and 2 (ERK1/2) and its dependence on D1 versus D2 dopamine receptors in
hemiparkinsonian rats treated with 3, 4-dihydroxyphenyl-L-alanine (L-DOPA). METHODS: 6-
Hydroxydopamine-lesioned rats were treated acutely or chronically with L-DOPA in
combination with antagonists for D1 or D2 receptors. Development of dyskinesia was
monitored in animals receiving chronic drug treatment. Phosphorylation of ERK1/2, mitogen …