Modulation of striatal projection systems by dopamine
CR Gerfen, DJ Surmeier - Annual review of neuroscience, 2011 - annualreviews.org
The basal ganglia are a chain of subcortical nuclei that facilitate action selection. Two striatal
projection systems—so-called direct and indirect pathways—form the functional backbone of
the basal ganglia circuit. Twenty years ago, investigators proposed that the striatum's ability
to use dopamine (DA) rise and fall to control action selection was due to the segregation of
D1 and D2 DA receptors in direct-and indirect-pathway spiny projection neurons. Although
this hypothesis sparked a debate, the evidence that has accumulated since then clearly …
projection systems—so-called direct and indirect pathways—form the functional backbone of
the basal ganglia circuit. Twenty years ago, investigators proposed that the striatum's ability
to use dopamine (DA) rise and fall to control action selection was due to the segregation of
D1 and D2 DA receptors in direct-and indirect-pathway spiny projection neurons. Although
this hypothesis sparked a debate, the evidence that has accumulated since then clearly …
