[HTML][HTML] Cytochrome P450-derived epoxyeicosatrienoic acids and coronary artery disease in humans: a targeted metabolomics study

A Oni-Orisan, ML Edin, JA Lee, MA Wells… - Journal of lipid …, 2016 - ASBMB
Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) exhibit potent
cardiovascular protective effects in preclinical models, and promoting the effects of EETs has
emerged as a potential therapeutic strategy for coronary artery disease (CAD). The
relationship between circulating EET levels and CAD extent in humans, however, remains
unknown. A panel of free (unesterified) plasma eicosanoid metabolites was quantified in
162 patients referred for coronary angiography, and associations with extent of CAD [no …