PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

C Cantó, J Auwerx - Current opinion in lipidology, 2009 - journals.lww.com
C Cantó, J Auwerx
Current opinion in lipidology, 2009journals.lww.com
Metabolic sensors such as AMPK and SIRT1, gatekeepers of the activity of the master
regulator of mitochondria, PGC-1α, are vital links in a regulatory network for metabolic
homeostasis. Together, these players explain many of the beneficial effects of physical
activity and dietary interventions in our battle against type 2 diabetes and related metabolic
disorders. Hence, understanding the mechanisms by which they act could guide us to
identify and improve preventive and therapeutic strategies for metabolic diseases.
Summary
Metabolic sensors such as AMPK and SIRT1, gatekeepers of the activity of the master regulator of mitochondria, PGC-1α, are vital links in a regulatory network for metabolic homeostasis. Together, these players explain many of the beneficial effects of physical activity and dietary interventions in our battle against type 2 diabetes and related metabolic disorders. Hence, understanding the mechanisms by which they act could guide us to identify and improve preventive and therapeutic strategies for metabolic diseases.
Lippincott Williams & Wilkins