[HTML][HTML] Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells

IK Guttilla, BA White - Journal of Biological Chemistry, 2009 - ASBMB
The FOXO1 transcription factor orchestrates the regulation of genes involved in the apoptotic
response, cell cycle checkpoints, and cellular metabolism. FOXO1 is a putative tumor
suppressor, and the expression of this gene is dysregulated in some cancers, including
prostate and endometrial cancers. However, the molecular mechanism resulting in aberrant
expression of human FOXO1 in cancer cells is poorly understood. We show here that
FOXO1 mRNA is down-regulated in breast tumor samples as compared with normal breast …