TRPV1 regulators mediate gentamicin penetration of cultured kidney cells

SE Myrdal, PS Steyger - Hearing research, 2005 - Elsevier
Transient receptor potential (TRP) receptors are, typically, calcium-permeant cation
channels that transduce environmental stimuli. Both kidney epithelial and inner ear sensory
cells express TRPV1, are mechanosensors and accumulate the aminoglycoside antibiotic
gentamicin. Recently, we showed that Texas Red-conjugated gentamicin (GTTR) enters
kidney cells via an endosome-independent pathway. Here, we used GTTR to investigate this
non-endocytotic mechanism of gentamicin uptake. In serum-free buffers, GTTR penetrated …