Blockage of the transduction channels of hair cells in the bullfrog's sacculus by aminoglycoside antibiotics
ABA Kroese, A Das, AJ Hudspeth - Hearing research, 1989 - Elsevier
The action of aminoglycoside antibiotics on transduction by hair cells was investigated in
isolated preparations of the bullfrog's sacculus. Bath application of aminoglycosides
produced a reversible blockage of extracellularly recorded responses to displacements of
the otolithic membrane. The half-blocking concentrations for various drugs were in the range
2–95 μM. The effect of dihydrostreptomycin on the receptor currents of individual hair cells
was studied under two-electrode, voltage-clamp conditions. Iontophoretic application of drug …
isolated preparations of the bullfrog's sacculus. Bath application of aminoglycosides
produced a reversible blockage of extracellularly recorded responses to displacements of
the otolithic membrane. The half-blocking concentrations for various drugs were in the range
2–95 μM. The effect of dihydrostreptomycin on the receptor currents of individual hair cells
was studied under two-electrode, voltage-clamp conditions. Iontophoretic application of drug …