Down-regulation of transcription factor peroxisome proliferator-activated receptor in programmed hepatic lipid dysregulation and inflammation in intrauterine growth …
TR Magee, G Han, B Cherian, O Khorram… - American journal of …, 2008 - Elsevier
OBJECTIVE: Intrauterine growth-restricted (IUGR) newborns have increased risk of obesity-
induced fatty liver and inflammation. We hypothesized that IUGR-induced inhibition of
hepatic peroxisome proliferator-activated receptors (PPARs) is associated with an increased
inflammatory response. STUDY DESIGN: Rat control dams received ad libitum food,
whereas study dams were 50% food restricted from pregnancy day 10 to 21 (IUGR). Pups
were nursed by control dams and weaned to ad libitum feed. Hepatic protein expression of …
induced fatty liver and inflammation. We hypothesized that IUGR-induced inhibition of
hepatic peroxisome proliferator-activated receptors (PPARs) is associated with an increased
inflammatory response. STUDY DESIGN: Rat control dams received ad libitum food,
whereas study dams were 50% food restricted from pregnancy day 10 to 21 (IUGR). Pups
were nursed by control dams and weaned to ad libitum feed. Hepatic protein expression of …