Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity
OT Hardy, RA Perugini, SM Nicoloro… - Surgery for Obesity and …, 2011 - Elsevier
BACKGROUND: Obesity is a strong risk factor for resistance to insulin-mediated glucose
disposal, a precursor of type 2 diabetes and other disorders. We sought to identify the
molecular pathways that might cause obesity-associated insulin resistance in humans by
studying the morbidly obese with a similar body mass index who were insulin sensitive
versus insulin resistant. We eliminated obesity as a variable by studying only morbidly
obese individuals, Also, not all obese individuals are prone to insulin resistance. METHODS …
disposal, a precursor of type 2 diabetes and other disorders. We sought to identify the
molecular pathways that might cause obesity-associated insulin resistance in humans by
studying the morbidly obese with a similar body mass index who were insulin sensitive
versus insulin resistant. We eliminated obesity as a variable by studying only morbidly
obese individuals, Also, not all obese individuals are prone to insulin resistance. METHODS …