[HTML][HTML] Metabolically induced liver inflammation leads to NASH and differs from LPS-or IL-1β-induced chronic inflammation
W Liang, JH Lindeman, AL Menke, DP Koonen… - Laboratory …, 2014 - Elsevier
The nature of the chronic inflammatory component that drives the development of non-
alcoholic steatohepatitis (NASH) is unclear and possible inflammatory triggers have not
been investigated systematically. We examined the effect of non-metabolic triggers
(lipopolysaccharide (LPS), interleukin-1β (IL-1β), administered by slow-release minipumps)
and metabolic dietary triggers (carbohydrate, cholesterol) of inflammation on the
progression of bland liver steatosis (BS) to NASH. Transgenic APOE3* Leiden. huCETP …
alcoholic steatohepatitis (NASH) is unclear and possible inflammatory triggers have not
been investigated systematically. We examined the effect of non-metabolic triggers
(lipopolysaccharide (LPS), interleukin-1β (IL-1β), administered by slow-release minipumps)
and metabolic dietary triggers (carbohydrate, cholesterol) of inflammation on the
progression of bland liver steatosis (BS) to NASH. Transgenic APOE3* Leiden. huCETP …