Prevention of diet-induced fatty liver in experimental animals by the oral administration of a fatty acid bile acid conjugate (FABAC)

T Gilat, A Leikin-Frenkel, I Goldiner, C Juhel, H Lafont… - Hepatology, 2003 - Elsevier
Fatty acid bile acid conjugates (FABACs) are a new family of synthetic molecules designed
to solubilize biliary cholesterol. They were shown to prevent and dissolve cholesterol
gallstones in inbred C57L/J mice fed a lithogenic, high-fat diet (HFD). In these mice, fatty
liver was observed in the controls but not in the FABAC-treated ones. The present study was
designed to study the effect of FABAC (arachidyl-amido-cholanoic acid) on diet-induced fatty
liver in rats, hamsters, and mice. The fatty liver score (on a scale of 0-4 by light microscopy) …