Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles
Background & Aims The mechanisms by which hepatocyte exposure to alcohol activates
inflammatory cells such as macrophages in alcoholic liver disease (ALD) are unclear. The
role of released nano-sized membrane vesicles, termed extracellular vesicles (EV), in cell-to-
cell communication has become increasingly recognized. We tested the hypothesis that
hepatocytes exposed to alcohol may increase EV release to elicit macrophage activation.
Methods Primary hepatocytes or HepG2 hepatocyte cell lines overexpressing ethanol …
inflammatory cells such as macrophages in alcoholic liver disease (ALD) are unclear. The
role of released nano-sized membrane vesicles, termed extracellular vesicles (EV), in cell-to-
cell communication has become increasingly recognized. We tested the hypothesis that
hepatocytes exposed to alcohol may increase EV release to elicit macrophage activation.
Methods Primary hepatocytes or HepG2 hepatocyte cell lines overexpressing ethanol …