The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91phox mediate hepatic fibrosis in mice

YH Paik, K Iwaisako, E Seki, S Inokuchi, B Schnabl… - Hepatology, 2011 - journals.lww.com
Nicotinamide adenine dinucleotide phosphate oxidase (NOX) is a multicomponent enzyme
that mediates electron transfer from nicotinamide adenine dinucleotide phosphate to
molecular oxygen, which leads to the production of superoxide. NOX2/gp91 phox is a
catalytic subunit of NOX expressed in phagocytic cells. Several homologues of NOX2,
including NOX1, have been identified in nonphagocytic cells. We investigated the
contributory role of NOX1 and NOX2 in hepatic fibrosis. Hepatic fibrosis was induced in wild …