[HTML][HTML] Glutathione levels discriminate between oxidative stress and transforming growth factor-β signaling in activated rat hepatic stellate cells
PJ De Bleser, G Xu, K Rombouts, V Rogiers… - Journal of biological …, 1999 - ASBMB
Reactive oxygen species are implicated in the pathogenesis of several diseases, including
Alzheimer's disease, multiple sclerosis, human immunodeficiency virus, and liver fibrosis.
With respect to liver fibrosis, we have investigated differences in antioxidant enzymes
expression in stellate cells (SCs) and parenchymal cells from normal and CCl 4-treated rat
livers. We observed an increase in the expression of catalase in activated SCs. Treatment
with transforming growth factor-β (TGF-β) increased the production of H 2 O 2. Treatment …
Alzheimer's disease, multiple sclerosis, human immunodeficiency virus, and liver fibrosis.
With respect to liver fibrosis, we have investigated differences in antioxidant enzymes
expression in stellate cells (SCs) and parenchymal cells from normal and CCl 4-treated rat
livers. We observed an increase in the expression of catalase in activated SCs. Treatment
with transforming growth factor-β (TGF-β) increased the production of H 2 O 2. Treatment …